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Fig. 5 | Cell & Bioscience

Fig. 5

From: IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis

Fig. 5

IFITM3 associates with MET/AKT complex in GC to transmit HGF signal and cancer progression. A Impacts of IFITM3-overexpression on signaling molecules MET, AKT, FOXO3 and c-MYC were determined by their phosphorylation status on western blots. B Protein extracts of Flag-IFITM3-overexpressing or control TMK-1 cells were immunoprecipitated with Flag antibody and analyzed for protein–protein interaction with MET and ATK on western blots. C Immunofluorescent imaging was conducted to show cellular co-localization between Flag-IFITM3 and MET or AKT. D Control or IFITM3-silenced AZ521cells that had been treated with or without HGF (20 nM) were used to assess the influences of IFITM3 on phosphorylation of MET and AKT, FOXO3 and c-MYC expressions. Cellular growth curves (E) and migration rates (F) of the indicated groups of AZ521 cells as in (D) were determined by measurements of viable or migrated cells after treatments (Right panel is the statistical results, **p < 0.01)

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Cell & Bioscience

ISSN: 2045-3701

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