Fig. 5
From: Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer
RNA-seq analysis of A549-derived xenografts. A. Principal component analysis plot of samples from RNA-seq analysis of control, Oxy186-treated, and Oxy210-treated xenografts. Bulk RNAs from seven samples (r1-r7) of each group were sequenced. Oxy186-treated sample r1-r4, but not r5-r7, showed a significant difference from the control samples. B. MA plot (log2 fold-change versus normalized expression) of differentially expressed (DE) genes in RNA-seq analysis of Oxy186-treated samples compared to control samples. Red dots: significantly DE genes (Fold > 2; Padj ≤ 0.05). C. KEGG pathway enrichment analysis of affected genes comparing RNA-seq data from Oxy186-treated vs control xenografts. Cut-off: Padj ≤ 0.05