Fig. 6

Anti-tumor ability of CUDC-907 in vivo. a On day 31, all mice were euthanized; primary tumor tissues were collected and imaged. b Weight of tumors derived from nude mice in the two groups. c Curve of tumor volume. d Expression levels in tumor tissues derived from two groups of nude mice were determined by western blot analysis to test the alteration of p-mTOR, p-IRE1α, LCN2, LC3B, and Ac-H3. e Representative images of Ki-67, p-mTOR, and p-IRE1α stained by immunohistochemical methods in control and treatment groups. f H-score methods were applied to evaluate immunohistochemical staining levels. Scale bar: 20 μm and 100 μm. Error bars are ± SD. *P < 0.05; **P < 0.01; ***P < 0.001