Fig. 7

Knockdown of SENP6 in microglia/macrophages promotes cognitive and motor function following focal ischaemic injury in mice. A The time to removal in adhesive removal tests. B The asymmetric rate in cylinder tests. C The latency time to fall off the rotarod drum during the final test. D–H) Latency trial (D, E) and probe trial (F, G) results in the MWM tests. D Escape latency to reach the hidden platform during Days 1 to 6 of testing. E Exploration time spent on the hidden platform on Day 6. F The times of crossing over the target platform location in probe trials on Day 7. G The time spent in the target quadrant. H Representative swimming traces on Day 7. Statistical differences in A–D were determined by RM ANOVA followed by Tukey’s post-hoc test. Data in F were assessed by the Kruskal–Wallis nonparametric test, and all others were assessed by one-way ANOVA followed by Tukey’s post-hoc test. n = 8 mice per group. Data are presented as the mean ± S.E.M. n.s. for P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001