Fig. 5
From: IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
The timeline of the C3aR blockade experiment (A). The effects of C3aR blockade by SB290157 on crossing number (B), rearing number (C), sucrose preference (D) and immobility time (E) in mice C3aR blockade reduced the levels of C3 (F) and C3aR (G). Representative photographs of Iba1(green)/C3aR(red)/DAPI(blue) (H). C3aR blockade inhibited microglial activation (I) and C3aR (J) expression. Data were obtained from 5–16 samples per group. #P < 0.05 and ##P < 0.01 versus the Control-vehicle group. *P < 0.05 and **P < 0.01 versus the CUMS-vehicle group