Fig. 1

Schematic abstract of the pathology of cerebral malaria. In both white and gray content, disease occurs differently. Although hemorrhagic spots abound in white matter, its presence in the gray matter remains unclear. Within these brain zones, the blood vessels of the brain are unique and can lead to PRBC driven by var gene expression, differential attachment of PfEMP1 and the resulting stimulation of opposite signaling pathways in the brain endothelial vascular system. Astroglial stimulation is enabled by the release of cytokines and chemokines into the brain from the irritated endothelial cells of BBB in connection with its activation to both neurotoxic plasma agents and dissolved Plasmodium triggers. This causes brain injury, together with the inflow of immune cells which contributes to the neurological effect after the CM