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Table 1 Carbohydrate metabolism genes showing increased transcript levels in male vs. female worms from barbel

From: Host-dependent impairment of parasite development and reproduction in the acanthocephalan model

Gene

Log2 fold change

Adjusted p-value

Function

Aldolase 1*

8.12

5.5E−11

Developmental stage-specific or tissue -specific sugar-phosphate metabolisms

Hexokinase A*

6.63

3.6E−09

Glucose homeostasis

Glyceraldehyde 3 phosphate dehydrogenase 2 *

5.47

2.4E−10

Glucose homeostasis

Phosphoglycerate kinase*

5.25

8.6E−11

Gluconeogenesis

NUCB1

3.84

2.3E−17

Carbohydrate metabolic process

Pyruvate kinase*

2.00

1.7E−17

Muscle development, glycolysis and glucose homeostasis

Glycogenin

1.62

9.1E−07

Glycogenin glucosyltransferase activity

Glycerol-3-phosphate dehydrogenase 1

1.37

2.7E−05

Enzymatic oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate

Glycogen phosphorylase

1.29

2.3E−06

Important allosteric enzyme in carbohydrate metabolism

Trehalose-6-phosphate synthase 1

1.26

2.3E−04

Enzymatic production of T6P using glucose-6-phosphate and UDP-glucose

N-acetylglucosamine kinase

1.20

3.6E-−04

Carbohydrate phosphorylation

Pyruvate carboxylase

1.18

2.7E−05

Gluconeogenesis

Hexosaminidase 1

1.18

8.3E−05

Protein deglycosylation and rhodopsin biosynthesis

Poly(ADP-ribose) glycohydrolase

1.16

9.1E−09

Degrades poly(ADP-ribose) to mono(ADP-ribose)

Glucosidase 2 α subunit

1.15

9.3E−05

Glucan 1,3-alpha-glucosidase activation; N-glycan processing

Oscillin

1.11

2.7E−05

Glucosamine-6-phosphate deaminase activation

Phosphoenolpyruvate carboxykinase 2*

1.06

1.3E−03

Manganese ion binding activation and phosphoenolpyruvate carboxykinase (GTP) activation

4-alpha-glucanotransferase

1.02

1.1E−09

4-alpha-glucanotransferase activation and amylo-alpha-1,6-glucosidase activation

Malate dehydrogenase 1

1.01

3.7E−05

Interconversion of malate and oxaloacetate

Glycogen synthase

1.01

1.3E−04

Enzymatic linkage of glucose monomers into glycogen

  1. Genes up-regulated in male worms from barbel were found enriched with the GO term “metabolism of carbohydrates”. Of those, the 20 genes with the highest (and significant) log2 fold change of transcript abundances are shown here. The functions indicated refer to annotations of homologs in Drosophila melanogaster (flybase.org). Genes marked with an asterisk are part of the KEGG pathway “glycolysis/gluconeogenesis” (see Additional File 1: Fig. S1)