Fig. 8
From: Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans
Schematic demonstrating integration of BMP signaling with anabolic and catabolic metabolism. Arrows indicate positive signaling interactions, whereas T-bars indicate negative signaling interactions. Solid blue arrows and T-bars indicate the primary effects of nutrients, nutrient starvation, and BMP signaling on metabolic signaling. BMP signaling promotes PI3K/Akt signaling and anabolism in response to abundant nutrients. By contrast, BMP signaling reduces AMPK signaling and catabolism in response to nutrient starvation. Dotted red arrows and T-bars indicate regulatory feedback by AMPK signaling and feedforward by PI3K/Akt signaling on BMP signaling