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Fig. 6 | Cell & Bioscience

Fig. 6

From: Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition

Fig. 6

Identification of unique signatures in major cell types of human amnion in membrane rupture at parturition. A–C The Venn diagram shows overlap in DEGs (≥ 1.5-fold changes, P < 0.05) between TL_P and TNL_P groups, and between TL_P and TL_D groups in epithelial cells (A), fibroblasts (B) and immunocytes (C). D–F CCL20 was revealed among the top up-regulated genes in epithelial cells (D), fibroblasts (E) and immunocytes (F) in TL_P group. G–I Inferred active transcription factors (TFs) across TL_P, TL_D and TNL_P groups in epithelial cells (G), fibroblasts (H) and immunocytes (I) by SCENIC analysis. Numbers in brackets indicate the regulons subject to respective TFs. TNL_P term non-labor-proximal, TL_P term labor-proximal (ZAM zone), TL_D term labor-distal (non-ZAM zone)

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Cell & Bioscience

ISSN: 2045-3701

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