RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence

Table 3 The details of glycolysis/gluconeogenesis pathway related genes

NO.	Gene name	Chromosome	Fold change	P value	FDR	Regulation
1	LDHB	4	0.324	9.015E-05	0.012	Down
2	PGM1	5	0.376	0.002	0.029	Down
3	HK1	20	0.638	0.002	0.030	Down
4	GPI	1	0.483	0.003	0.036	Down
5	PFKM	7	0.378	0.003	0.036	Down
6	PFKL	20	0.368	0.005	0.043	Down
7	PK	8	0.529	0.008	0.052	Down
8	ACSS2	3	0.338	0.011	0.060	Down
9	ALDH3A2	10	0.634	0.011	0.060	Down
10	LDHA	1	0.493	0.012	0.062	Down
11	ALDOC	10	0.249	0.012	0.064	Down
12	PGAM1	1	0.496	0.014	0.069	Down
13	HK2	4	0.508	0.015	0.070	Down
14	GAPDH	4	0.546	0.016	0.072	Down
15	TPI1	4	0.435	0.019	0.079	Down
16	ALDOA	1	0.664	0.022	0.084	Down
17	PGK1	X	0.471	0.027	0.095	Down
18	ALDH7A1	18	0.608	0.029	0.100	Down
19	ENO1	5	0.657	0.031	0.102	Down
20	GALM	6	0.579	0.044	0.124	Down

FDR the adjusted P value, P value the P value of the F-statistic for gene from young and old MSCs, AcCSS2 acyl-CoA synthetase short-chain family member 2, ALDH3A2 aldehyde dehydrogenase 3 family member A2, ALDH7A1 aldehyde dehydrogenase 7 family member A1, ALDOA aldolase fructose-bisphosphate, ALDOC aldolase fructose-bisphosphate C, ENO1 enolase 1, GALM galactose mutarotase, GAPDH glyceraldehyde-3-phosphate dehydrogenase, PFKL phosphofructokinase liver type, PFKM phosphofructokinase muscle, PGK1 phosphoglycerate kinase 1, PGM1 phosphoglucomutase 1, PK pyruvate kinase, GPI glucose-6-phosphate isomerase, HK1 hexokinase 1, HK2 hexokinase 2, LDHA lactate dehydrogenase A, LDHB lactate dehydrogenase B, PGAM1 phosphoglycerate mutase 1, TPI1 triosephosphate isomerase 1

ISSN: 2045-3701