Fig. 5
From: Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants
Structural analysis of R3P1-E4 and SARS-CoV-2 RBD complex. A The overall complex structure of R3P1-E4-RBD superimposed with the hACE2-RBD complex. The R3P1-E4 heavy chain (colored cyan), light chain (colored violet) and hACE2 (colored pale green) are displayed in cartoon representation. The SARS-CoV-2 RBD is colored in gray and displayed in surface representation. B The epitope recognized by R3P1-E4 is shown in surface representation. The CDR loops of heavy chain (HCDR) and light chain (LCDR) are colored in green cyan and salmon, respectively. The epitopes from the heavy chain and light chain are colored in cyan and violet, respectively. The residues of R403, K417 and R493, which contacts with both heavy chain and light chain, is colored in light blue. The identical residues from RBD participating in the binding of R3P1-E4 and hACE2 are labeled in red. These residues are numbered according to SARS-CoV-2 RBD. C The detailed interactions between SARS-CoV-2 RBD with HCDRs and LCDRs. The residues are shown in sticks with identical colors to (B)