Fig. 3
From: BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma
GNE987 inhibited the NB cell cycle and induced apoptosis. A NB cells were treated with GNE987 for 24 h and the cell cycle distribution of NB cells was analysed using flow cytometry. B Western blotting analysis showing the expression of cyclin D2, cleaved caspase-3, and cleaved PARP in the NB cells treated with vehicle (DMSO) or increasing concentrations of GNE987 for 24 h. C, D Annexin-V/PI staining and flow cytometry were performed to detect apoptosis in the NB cells treated with vehicle (DMSO) or the specified concentrations of GNE987. *p < 0.05, **p < 0.01, ***p < 0.001