Fig. 2
From: BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma
GNE987 inhibited NB cell viability and proliferation. A BET protein levels in NB cells were assessed using Western blotting. B Survival rate curves of the SK-N-BE (2), IMR-32, SK-N-SH, and SH-SY5Y cells after treatment with vehicle (DMSO) or increasing concentrations of GNE987 for 24 h. Data are shown by percent cell viability relative to that of the DMSO-treated cells. C The IC50 value of GNE987 in different NB cell lines. D Microscopic images of the SK-N-BE (2), IMR-32, SK-N-SH and SH-SY5Y cells treated with vehicle (DMSO) and the specified concentrations of GNE987 for 24 h (red arrows indicate dead cells after GNE987 treatment). E, F The clonal formation ability of the NB cells treated with the vehicle or a series of concentrations of GNE987 as assessed using a clone formation assay. ***p < 0.001, ****p < 0.0001; ns, not significant