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Table 3 2SMR estimates of the causality between antidiabetic targets and AD

From: Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease

Target gene Drugs Action Method Numbers of SNPs OR 95% CI P-value
CPE Insulin Human Modulator (Unknown) MR Egger 3 0.98 0.82–1.17 0.86
Inverse variance weighted 3 0.94 0.89–1.00 0.05
Weighted median 3 0.95 0.89–1.01 0.08
Weighted mode 3 0.95 0.89–1.01 0.24
ETFDH Metformin Inhibitor Inverse variance weighted 2 1.08 1.01–1.16 0.03
GANC Miglitol Antagonist Inverse variance weighted 2 1.09 1.02–1.18 0.02
MGAM Voglibose Inhibitor Wald ratio 1 1.04 1.00–1.09 0.04
Acarbose Inhibitor
Miglitol Antagonist,
inhibitor