Table 2 Main characteristics of the antidiabetic drugs included in the PPI network
Name | Drugbank ID | Target genes | Target type |
|---|---|---|---|
Ebselen | DB12610 | EPHX2 | Target |
INCB13739 | DB05064 | HSD11B1 | Target |
PSN357 | DB05044 | PYGL | Target |
Bisegliptin | DB06127 | DPP4 | Target |
NOX-700 | DB05464 | NFKB2 | Target |
NFKB1 | Target | ||
CLX-0921 | DB05854 | PPARG | Target |
Reglitazar | DB04971 | PPARA | Target |
PPARG | Target | ||
ISIS 113715 | DB05506 | PTPN1 | Target |
AT1391 | DB05120 | INSR | Target |
NN344 | DB05115 | INSR | Target |
CYP1A2 | Enzyme | ||
APD668 | DB05166 | GPR119 | Target |
Dutogliptin | DB11723 | DPP4 | Target |
MB-07803 | DB05053 | FBP1 | Target |
PSN9301 | DB05001 | DPP4 | Target |
Gliquidone | DB01251 | ABCC8 | Target |
KCNJ8 | Target | ||
CYP2C9 | Enzyme | ||
Albiglutide | DB09043 | GLP1R | Target |
Pramlintide | DB01278 | CALCR | Target |
RAMP1 | Target | ||
RAMP2 | Target | ||
RAMP3 | Target | ||
Voglibose | DB04878 | MGAM | Target |
Dapagliflozin | DB06292 | SLC5A2 | Target |
CYP1A1 | Enzyme | ||
CYP1A2 | Enzyme | ||
CYP2A6 | Enzyme | ||
CYP2C9 | Enzyme | ||
CYP2D6 | Enzyme | ||
CYP3A4 | Enzyme | ||
UGT1A9 | Enzyme | ||
UGT2B4 | Enzyme | ||
UGT2B7 | Enzyme | ||
Miglitol | DB00491 | MGAM | Target |
GAA | Target | ||
GANAB | Target | ||
GANC | Target | ||
AMY2A | Enzyme | ||
Vildagliptin | DB04876 | DPP4 | Target |
Dulaglutide | DB09045 | GLP1R | Target |
Phenformin | DB00914 | PRKAA1 | Target |
KCNJ8 | Target | ||
CYP2D6 | Enzyme | ||
AMG-131 | DB05490 | PPARG | Target |
Acarbose | DB00284 | MGAM | Target |
GAA | Target | ||
SI | Target | ||
AMY2A | Target | ||
Sitagliptin | DB01261 | DPP4 | Target |
CYP3A4 | Enzyme | ||
CYP2C8 | Enzyme | ||
Acetohexamide | DB00414 | KCNJ1 | Target |
CBR1 | Enzyme | ||
CYP2C9 | Enzyme | ||
Canagliflozin | DB08907 | SLC5A2 | Target |
UGT1A9 | Enzyme | ||
UGT2B4 | Enzyme | ||
CYP3A4 | Enzyme | ||
Pioglitazone | DB01132 | PPARG | Target |
MAOB | Target | ||
CYP2C8 | Enzyme | ||
CYP3A4 | Enzyme | ||
CYP1A1 | Enzyme | ||
Glisoxepide | DB01289 | KCNJ8 | Target |
CYP2C9 | Enzyme | ||
Glipizide | DB01067 | ABCC8 | Target |
PPARG | Target | ||
CYP2C9 | Enzyme | ||
UGT1A1 | Enzyme | ||
Insulin Glargine | DB00047 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
Insulin Degludec | DB09564 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
Chlorpropamide | DB00672 | ABCC8 | Target |
CYP2C9 | Enzyme | ||
CYP2C19 | Enzyme | ||
PTGS1 | Enzyme | ||
Linagliptin | DB08882 | DPP4 | Target |
CYP3A4 | Enzyme | ||
Repaglinide | DB00912 | ABCC8 | Target |
PPARG | Target | ||
CYP2C8 | Enzyme | ||
CYP3A4 | Enzyme | ||
Insulin Pork | DB00071 | INSR | Target |
IGF1R | Target | ||
IDE | Enzyme | ||
CYP1A2 | Enzyme | ||
Nateglinide | DB00731 | ABCC8 | Target |
PPARG | Target | ||
CYP2C9 | Enzyme | ||
CYP3A4 | Enzyme | ||
CYP3A5 | Enzyme | ||
CYP3A7 | Enzyme | ||
PTGS1 | Enzyme | ||
UGT1A9 | Enzyme | ||
CYP2D6 | Enzyme | ||
Insulin Aspart | DB01306 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
Insulin Detemir | DB01307 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
Saxagliptin | DB06335 | DPP4 | Target |
CYP3A4 | Enzyme | ||
CYP3A5 | Enzyme | ||
Insulin Glulisine | DB01309 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
Tolbutamide | DB01124 | ABCC8 | Target |
KCNJ1 | Target | ||
CYP2C9 | Enzyme | ||
CYP2C8 | Enzyme | ||
CYP2C19 | Enzyme | ||
CYP2C18 | Enzyme | ||
Rosiglitazone | DB00412 | PPARG | Target |
ACSL4 | Target | ||
PPARA | Target | ||
PPARD | Target | ||
RXRA | Target | ||
RXRB | Target | ||
RXRG | Target | ||
CYP2C8 | Enzyme | ||
CYP2C9 | Enzyme | ||
PTGS1 | Enzyme | ||
CYP1A2 | Enzyme | ||
CYP3A4 | Enzyme | ||
CYP2B6 | Enzyme | ||
CYP2D6 | Enzyme | ||
CYP2E1 | Enzyme | ||
Mitiglinide | DB01252 | ABCC8 | Target |
PPARG | Target | ||
UGT1A3 | Enzyme | ||
UGT2B7 | Enzyme | ||
Insulin Human | DB00030 | INSR | Target |
IGF1R | Target | ||
CPE | Target | ||
NOV | Target | ||
LRP2 | Target | ||
IGFBP7 | Target | ||
IDE | Enzyme | ||
PCSK2 | Enzyme | ||
PCSK1 | Enzyme | ||
CYP1A2 | Enzyme | ||
Insulin Lispro | DB00046 | INSR | Target |
IGF1R | Target | ||
CYP1A2 | Enzyme | ||
IDE | Enzyme | ||
Lixisenatide | DB09265 | GLP1R | Target |
Metformin | DB00331 | PRKAB1 | Target |
ETFDH | Target | ||
GPD1 | Target | ||
Lobeglitazone | DB09198 | PPARG | Target |
CYP1A2 | Enzyme | ||
CYP2C9 | Enzyme | ||
CYP2C19 | Enzyme | ||
CYP3A4 | Enzyme | ||
Managlinat dialanetil | DB05518 | FBP1 | Target |
Levoketoconazole | DB05667 | CYP11B1 | Target |
CYP51A1 | Target | ||
CYP3A4 | Enzyme | ||
CYP3A5 | Enzyme | ||
CYP51A1 | Enzyme | ||
CYP17A1 | Enzyme | ||
CYP21A2 | Enzyme | ||
CYP11B1 | Enzyme | ||
Tesaglitazar | DB06536 | PPARA | Target |
PPARG | Target | ||
Ertiprotafib | DB06521 | PTPN1 | Target |
IKBKB | Target | ||
PPARA | Target | ||
PPARG | Target | ||
Glycodiazine | DB01382 | KCNJ1 | Target |
ABCC8 | Target | ||
Muraglitazar | DB06510 | PPARA | Target |
PPARG | Target | ||
CYP1A2 | Enzyme | ||
UGT1A3 | Enzyme | ||
UGT1A1 | Enzyme | ||
CYP2C8 | Enzyme | ||
Troglitazone | DB00197 | PPARG | Target |
ACSL4 | Target | ||
SERPINE1 | Target | ||
SLC29A1 | Target | ||
ESRRG | Target | ||
ESRRA | Target | ||
PPARD | Target | ||
PPARA | Target | ||
GSTP1 | Target | ||
CYP3A4 | Enzyme | ||
CYP2C19 | Enzyme | ||
UGT1A1 | Enzyme | ||
CYP2C8 | Enzyme | ||
CYP19A1 | Enzyme | ||
CYP1A1 | Enzyme | ||
CYP2B6 | Enzyme | ||
CYP2C9 | Enzyme | ||
CYP3A5 | Enzyme | ||
CYP3A7 | Enzyme | ||
UGT1A3 | Enzyme | ||
UGT1A4 | Enzyme | ||
UGT1A6 | Enzyme | ||
UGT1A7 | Enzyme | ||
UGT1A8 | Enzyme | ||
UGT1A9 | Enzyme | ||
UGT1A10 | Enzyme | ||
UGT2B7 | Enzyme | ||
UGT2B15 | Enzyme | ||
Ertugliflozin | DB11827 | SLC5A2 | Target |
UGT1A9 | Enzyme | ||
UGT2B7 | Enzyme | ||
UGT1A1 | Enzyme | ||
UGT1A4 | Enzyme | ||
Exenatide | DB01276 | GLP1R | Target |
DPP4 | Enzyme | ||
Naveglitazar | DB12662 | PPARG | Target |
Alogliptin | DB06203 | DPP4 | Target |
CYP3A4 | Enzyme | ||
CYP2D6 | Enzyme | ||
Liraglutide | DB06655 | GLP1R | Target |
DPP4 | Enzyme | ||
MME | Enzyme | ||
Semaglutide | DB13928 | GLP1R | Target |
DPP4 | Enzyme | ||
MME | Enzyme | ||
LPL | Enzyme | ||
AMY1A | Enzyme | ||
Glimepiride | DB00222 | KCNJ11 | Target |
KCNJ1 | Target | ||
ABCC8 | Target | ||
CYP2C9 | Enzyme | ||
Sarpogrelate | DB12163 | HTR2C | Target |
HTR2A | Target | ||
Glyburide | DB01016 | ABCC9 | Target |
ABCB11 | Target | ||
ABCA1 | Target | ||
CFTR | Target | ||
CPT1A | Target | ||
TRPM4 | Target | ||
CYP2C9 | Enzyme | ||
CYP2C19 | Enzyme | ||
CYP3A4 | Enzyme | ||
CYP3A7 | Enzyme | ||
CYP3A5 | Enzyme | ||
Gliclazide | DB01120 | ABCC8 | Target |
VEGFA | Target | ||
CYP2C9 | Enzyme | ||
CYP2C19 | Enzyme | ||
Empagliflozin | DB09038 | SLC5A2 | Target |
UGT2B7 | Enzyme | ||
UGT1A3 | Enzyme | ||
UGT1A8 | Enzyme | ||
UGT1A9 | Enzyme | ||
Glymidine | DB01382 | KCNJ1 | Target |
ABCC8 | Target | ||
Balaglitazone | DB12781 | CYP3A4 | Enzyme |
CYP2C8 | Enzyme | ||
Glibornuride | DB08962 | CYP2C9 | Enzyme |
Rivoglitazone | DB09200 | CYP3A4 | Enzyme |
CYP2C8 | Enzyme | ||
AB192 | DB06111 | MPO | Enzyme |
Lisofylline | DB12406 | CYP1A2 | Enzyme |