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Table 2 Main characteristics of the antidiabetic drugs included in the PPI network

From: Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease

Name Drugbank ID Target genes Target type
Ebselen DB12610 EPHX2 Target
INCB13739 DB05064 HSD11B1 Target
PSN357 DB05044 PYGL Target
Bisegliptin DB06127 DPP4 Target
NOX-700 DB05464 NFKB2 Target
   NFKB1 Target
CLX-0921 DB05854 PPARG Target
Reglitazar DB04971 PPARA Target
   PPARG Target
ISIS 113715 DB05506 PTPN1 Target
AT1391 DB05120 INSR Target
NN344 DB05115 INSR Target
   CYP1A2 Enzyme
APD668 DB05166 GPR119 Target
Dutogliptin DB11723 DPP4 Target
MB-07803 DB05053 FBP1 Target
PSN9301 DB05001 DPP4 Target
Gliquidone DB01251 ABCC8 Target
   KCNJ8 Target
   CYP2C9 Enzyme
Albiglutide DB09043 GLP1R Target
Pramlintide DB01278 CALCR Target
   RAMP1 Target
   RAMP2 Target
   RAMP3 Target
Voglibose DB04878 MGAM Target
Dapagliflozin DB06292 SLC5A2 Target
   CYP1A1 Enzyme
   CYP1A2 Enzyme
   CYP2A6 Enzyme
   CYP2C9 Enzyme
   CYP2D6 Enzyme
   CYP3A4 Enzyme
   UGT1A9 Enzyme
   UGT2B4 Enzyme
   UGT2B7 Enzyme
Miglitol DB00491 MGAM Target
   GAA Target
   GANAB Target
   GANC Target
   AMY2A Enzyme
Vildagliptin DB04876 DPP4 Target
Dulaglutide DB09045 GLP1R Target
Phenformin DB00914 PRKAA1 Target
   KCNJ8 Target
   CYP2D6 Enzyme
AMG-131 DB05490 PPARG Target
Acarbose DB00284 MGAM Target
   GAA Target
   SI Target
   AMY2A Target
Sitagliptin DB01261 DPP4 Target
   CYP3A4 Enzyme
   CYP2C8 Enzyme
Acetohexamide DB00414 KCNJ1 Target
   CBR1 Enzyme
   CYP2C9 Enzyme
Canagliflozin DB08907 SLC5A2 Target
   UGT1A9 Enzyme
   UGT2B4 Enzyme
   CYP3A4 Enzyme
Pioglitazone DB01132 PPARG Target
   MAOB Target
   CYP2C8 Enzyme
   CYP3A4 Enzyme
   CYP1A1 Enzyme
Glisoxepide DB01289 KCNJ8 Target
   CYP2C9 Enzyme
Glipizide DB01067 ABCC8 Target
   PPARG Target
   CYP2C9 Enzyme
   UGT1A1 Enzyme
Insulin Glargine DB00047 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
Insulin Degludec DB09564 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
Chlorpropamide DB00672 ABCC8 Target
   CYP2C9 Enzyme
   CYP2C19 Enzyme
   PTGS1 Enzyme
Linagliptin DB08882 DPP4 Target
   CYP3A4 Enzyme
Repaglinide DB00912 ABCC8 Target
   PPARG Target
   CYP2C8 Enzyme
   CYP3A4 Enzyme
Insulin Pork DB00071 INSR Target
   IGF1R Target
   IDE Enzyme
   CYP1A2 Enzyme
Nateglinide DB00731 ABCC8 Target
   PPARG Target
   CYP2C9 Enzyme
   CYP3A4 Enzyme
   CYP3A5 Enzyme
   CYP3A7 Enzyme
   PTGS1 Enzyme
   UGT1A9 Enzyme
   CYP2D6 Enzyme
Insulin Aspart DB01306 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
Insulin Detemir DB01307 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
Saxagliptin DB06335 DPP4 Target
   CYP3A4 Enzyme
   CYP3A5 Enzyme
Insulin Glulisine DB01309 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
Tolbutamide DB01124 ABCC8 Target
   KCNJ1 Target
   CYP2C9 Enzyme
   CYP2C8 Enzyme
   CYP2C19 Enzyme
   CYP2C18 Enzyme
Rosiglitazone DB00412 PPARG Target
   ACSL4 Target
   PPARA Target
   PPARD Target
   RXRA Target
   RXRB Target
   RXRG Target
   CYP2C8 Enzyme
   CYP2C9 Enzyme
   PTGS1 Enzyme
   CYP1A2 Enzyme
   CYP3A4 Enzyme
   CYP2B6 Enzyme
   CYP2D6 Enzyme
   CYP2E1 Enzyme
Mitiglinide DB01252 ABCC8 Target
   PPARG Target
   UGT1A3 Enzyme
   UGT2B7 Enzyme
Insulin Human DB00030 INSR Target
   IGF1R Target
   CPE Target
   NOV Target
   LRP2 Target
   IGFBP7 Target
   IDE Enzyme
   PCSK2 Enzyme
   PCSK1 Enzyme
   CYP1A2 Enzyme
Insulin Lispro DB00046 INSR Target
   IGF1R Target
   CYP1A2 Enzyme
   IDE Enzyme
Lixisenatide DB09265 GLP1R Target
Metformin DB00331 PRKAB1 Target
   ETFDH Target
   GPD1 Target
Lobeglitazone DB09198 PPARG Target
   CYP1A2 Enzyme
   CYP2C9 Enzyme
   CYP2C19 Enzyme
   CYP3A4 Enzyme
Managlinat dialanetil DB05518 FBP1 Target
Levoketoconazole DB05667 CYP11B1 Target
   CYP51A1 Target
   CYP3A4 Enzyme
   CYP3A5 Enzyme
   CYP51A1 Enzyme
   CYP17A1 Enzyme
   CYP21A2 Enzyme
   CYP11B1 Enzyme
Tesaglitazar DB06536 PPARA Target
   PPARG Target
Ertiprotafib DB06521 PTPN1 Target
   IKBKB Target
   PPARA Target
   PPARG Target
Glycodiazine DB01382 KCNJ1 Target
   ABCC8 Target
Muraglitazar DB06510 PPARA Target
   PPARG Target
   CYP1A2 Enzyme
   UGT1A3 Enzyme
   UGT1A1 Enzyme
   CYP2C8 Enzyme
Troglitazone DB00197 PPARG Target
   ACSL4 Target
   SERPINE1 Target
   SLC29A1 Target
   ESRRG Target
   ESRRA Target
   PPARD Target
   PPARA Target
   GSTP1 Target
   CYP3A4 Enzyme
   CYP2C19 Enzyme
   UGT1A1 Enzyme
   CYP2C8 Enzyme
   CYP19A1 Enzyme
   CYP1A1 Enzyme
   CYP2B6 Enzyme
   CYP2C9 Enzyme
   CYP3A5 Enzyme
   CYP3A7 Enzyme
   UGT1A3 Enzyme
   UGT1A4 Enzyme
   UGT1A6 Enzyme
   UGT1A7 Enzyme
   UGT1A8 Enzyme
   UGT1A9 Enzyme
   UGT1A10 Enzyme
   UGT2B7 Enzyme
   UGT2B15 Enzyme
Ertugliflozin DB11827 SLC5A2 Target
   UGT1A9 Enzyme
   UGT2B7 Enzyme
   UGT1A1 Enzyme
   UGT1A4 Enzyme
Exenatide DB01276 GLP1R Target
   DPP4 Enzyme
Naveglitazar DB12662 PPARG Target
Alogliptin DB06203 DPP4 Target
   CYP3A4 Enzyme
   CYP2D6 Enzyme
Liraglutide DB06655 GLP1R Target
   DPP4 Enzyme
   MME Enzyme
Semaglutide DB13928 GLP1R Target
   DPP4 Enzyme
   MME Enzyme
   LPL Enzyme
   AMY1A Enzyme
Glimepiride DB00222 KCNJ11 Target
   KCNJ1 Target
   ABCC8 Target
   CYP2C9 Enzyme
Sarpogrelate DB12163 HTR2C Target
   HTR2A Target
Glyburide DB01016 ABCC9 Target
   ABCB11 Target
   ABCA1 Target
   CFTR Target
   CPT1A Target
   TRPM4 Target
   CYP2C9 Enzyme
   CYP2C19 Enzyme
   CYP3A4 Enzyme
   CYP3A7 Enzyme
   CYP3A5 Enzyme
Gliclazide DB01120 ABCC8 Target
   VEGFA Target
   CYP2C9 Enzyme
   CYP2C19 Enzyme
Empagliflozin DB09038 SLC5A2 Target
   UGT2B7 Enzyme
   UGT1A3 Enzyme
   UGT1A8 Enzyme
   UGT1A9 Enzyme
Glymidine DB01382 KCNJ1 Target
   ABCC8 Target
Balaglitazone DB12781 CYP3A4 Enzyme
   CYP2C8 Enzyme
Glibornuride DB08962 CYP2C9 Enzyme
Rivoglitazone DB09200 CYP3A4 Enzyme
   CYP2C8 Enzyme
AB192 DB06111 MPO Enzyme
Lisofylline DB12406 CYP1A2 Enzyme