Fig. 1
From: TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes
TSLP increased ROS production and mitochondrial complex activity in THP-1 cells. A TSLP treatment for 2 h induced ROS production in THP-1 cells. B Pretreatment with N-acetylcysteine (NAC), a well-established antioxidant, significantly suppressed TSLP-induced (40 ng/mL) ROS expression in THP-1 cells. C TSLP increased mitochondrial complex I activity in THP-1 cells. D TSLP increased mitochondrial complex II/III activity in THP-1 cells. Each bar represents the mean ± standard deviation of three independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001