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Table 2 miRNAs involved in cancer therapy-induced cardiotoxicity

From: Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology

miRNA Orthologs Drug or type of chemotherapy Expression Targets Cell type Biological effect Ref.
miR-152 Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
DOX down NRF2 CMs Apoptosis, oxidative damage, myocardial inflammation [281]
miR-133b Homo sapiens
Mus musculus
Rattus norvegicus
DOX down PTB1, TGLN2 CMs
In vivo
Apoptosis, cardiac fibrosis [293]
miR-98 Homo sapiens
Mus musculus
Rattus norvegicus
DOX Up Fas, RIP3 CMs Apoptosis [357]
miR-499-5p Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
DOX Overexpression P21 CMs and Heart Improved CM hypertrophy and cardiac function [358]
miR-29b Homo sapiens
Mus musculus
Rattus norvegicus
DOX Down Bax, BCL2 CMs and myocardium Apoptosis, mitochondrial membrane depolarization [305]
miR-29a-3p Homo sapiens
Mus musculus
Radiation Down Unknown Secreted exosomes Cardiac fibrosis [306]
miR-215-5p Homo sapiens
Mus musculus
DOX Up ZEB2 CMs Apoptosis [309, 310]
miR-200c Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
DOX Up ZEB1 Cardiac mesenchymal progenitor cells Cardiac progenitor cell depletion [314]
miR-22 Homo sapiens
Mus musculus
Rattus norvegicus
DOX Up SIRT1 CMs Apoptosis, oxidative stress [359]
miR-34a-5p Homo sapiens
Mus musculus
Epirubicin Up SIRT1 Myocardium and plasma Apoptosis, heart failure [317]
miR-1 Homo sapiens
Rattus norvegicus
As2O3 Up KCNJ2, ERG CMs impaired CM electrophysiology [321]
miR-320a Homo sapiens
Mus musculus
Rattus norvegicus
DOX Up VEGF-A ECs Apoptosis [322]
miR-526b-3p Homo sapiens DOX Up CD31, CD34, STAT3 ECs Abnormal capillaries microvasculature, vascular homeostasis [323]
miR-23a Homo sapiens
Mus musculus
DOX Up PGC-1α CMs Mitochondrial injury, apoptosis [324]
miR-221/222 Homo sapiens
Mus musculus
Rattus norvegicus
Radiation Up c-KIT ECs Angiogenesis [330, 331]