Table 2 miRNAs involved in cancer therapy-induced cardiotoxicity

miR-152

Homo sapiens

Mus musculus

Rattus norvegicus

Danio rerio

DOX

down

NRF2

CMs

Apoptosis, oxidative damage, myocardial inflammation

[281]

miR-133b

Homo sapiens

Mus musculus

Rattus norvegicus

DOX

down

PTB1, TGLN2

CMs

In vivo

Apoptosis, cardiac fibrosis

[293]

miR-98

Homo sapiens

Mus musculus

Rattus norvegicus

DOX

Up

Fas, RIP3

CMs

Apoptosis

[357]

miR-499-5p

Homo sapiens

Mus musculus

Rattus norvegicus

Danio rerio

DOX

Overexpression

P21

CMs and Heart

Improved CM hypertrophy and cardiac function

[358]

miR-29b

Homo sapiens

Mus musculus

Rattus norvegicus

DOX

Down

Bax, BCL2

CMs and myocardium

Apoptosis, mitochondrial membrane depolarization

[305]

miR-29a-3p

Homo sapiens

Mus musculus

Radiation

Down

Unknown

Secreted exosomes

Cardiac fibrosis

[306]

miR-215-5p

Homo sapiens

Mus musculus

DOX

Up

ZEB2

CMs

Apoptosis

[309, 310]

miR-200c

Homo sapiens

Mus musculus

Rattus norvegicus

Danio rerio

DOX

Up

ZEB1

Cardiac mesenchymal progenitor cells

Cardiac progenitor cell depletion

[314]

miR-22

Homo sapiens

Mus musculus

Rattus norvegicus

DOX

Up

SIRT1

CMs

Apoptosis, oxidative stress

[359]

miR-34a-5p

Homo sapiens

Mus musculus

Epirubicin

Up

SIRT1

Myocardium and plasma

Apoptosis, heart failure

[317]

miR-1

Homo sapiens

Rattus norvegicus

As₂O₃

Up

KCNJ2, ERG

CMs

impaired CM electrophysiology

[321]

miR-320a

Homo sapiens

Mus musculus

Rattus norvegicus

DOX

Up

VEGF-A

ECs

Apoptosis

[322]

miR-526b-3p

Homo sapiens

DOX

Up

CD31, CD34, STAT3

ECs

Abnormal capillaries microvasculature, vascular homeostasis

[323]

miR-23a

Homo sapiens

Mus musculus

DOX

Up

PGC-1α

CMs

Mitochondrial injury, apoptosis

[324]

miR-221/222

Homo sapiens

Mus musculus

Rattus norvegicus

Radiation

Up

c-KIT

ECs

Angiogenesis

[330, 331]