Fig. 6

Differentially expressed RNAs are closely associated with disease progression. A Network association between diseases and differentially expressed RNAs. The highlighted blue color node represents the disease associated with the RNAs, the green node represents the differentially expressed mRNAs and the red node represents the differentially expressed lncRNAs. B UpSet plot shows the number of differentially expressed RNAs in the subnetwork with six expression patterns in M—H and S—M comparisons. The bar and line charts show the trend of each group, and the arrows outline the position of the candidate mRNA. C Consistently downregulated or upregulated mRNA expression. Gray dots indicate healthy donors in the present study cohort; red dots indicate mild patients in the present study cohort; light green dots indicate mild patients in Bhanu’s cohort; and deep green dots indicate severe patients in Bhanu’s cohort. M, mild; H, health; S, severe; lncRNAs, long non-coding RNAs