Fig. 2
From: Genetically modified large animal models for investigating neurodegenerative diseases
Strategies to generate monkey models of neurodegenerative diseases. Genetic modifications in monkey embryos can be achieved by microinjection of transgene or CRISPR/Cas9 to target the endogenous gene. Alternatively, stereotaxic injection of viral vectors expressing transgene or CRISPR/Cas9 into specific brain regions of adult monkey can result in brain region-dependent gene editing