Fig. 4

HD-AD_RBD prevents lung inflammation after viral challenge. A Fold change in gene expression of the indicated cytokines and chemokines from lung homogenates at day 3 post infection was determined by qRT-PCR after normalization to GAPDH levels and comparison with the naive unchallenged control. Each dot represents an animal. Bars and errors represent the mean with SD. Statistical analyses were performed by Mann–Whitney test: *p < 0.05; **p < 0.01; ***p < 0.001. B H&E staining of lung sections of hACE2 mice at day 3 post infection. Images show low- (left, scale bar, 1 mm) and high- (right, scale bar, 100 µm) power magnification. Images are representative of n = 6 per group