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Fig. 1 | Cell & Bioscience

Fig. 1

From: Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

Fig. 1

Gene expression of EPB41L4A-AS1, DEGs screening, and module clustering. A Gene expression of EPB41L4A-AS1 in 13 brain regions with different ages. Data are shown as median with interquartile range, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. B Gene expression of EPB41L4A-AS1 in normal and Alzheimer's disease samples. C Volcano plot of genes in the hippocampus, blue, red, and grey dots represent downregulated, upregulated genes and genes without differential expression (the elderly group versus the young group). D Sample clustering to detect outliners, the height limit is 10000, and the samples in blue (height > 10,000) are outliers. E Scale independence of the scale-free networks, the limit of signed R2 of scale-free topology module fit is 0.8, and powers that make the R2 greater than 0.8 are appropriate for the networks. F Mean connectivity of the scale-free networks. G Cluster dendrogram of DEGs, the grey module holds the genes which were failed to cluster

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