Fig. 1
From: Parkinson's in the bone
PD risk genes that regulate Wnt/β-catenin signaling and bone homeostasis. A Retromer complex (including Vps35) promotes Wnt secretion by recycling Wntless from endosomes to the trans-Golgi network (TGN). VPS35-D620N, a mutant in PD patients, inhibits this event, reducing Wnt secretion. B LRRK2 binds to the β-catenin destruction complex. Gain of LRRK2 function/PD pathogenic LRRK2 mutants repress β-catenin signaling; and loss of LRRK2 increases canonical Wnt/b-catenin signaling