Fig. 2
From: Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
Evolutionarily conserved Insulin/IGF-1 signaling pathway and JNK signaling pathway for FoxO regulation. The binding of Insulin or IGF-1 to the receptors trigger a kinase cascade, which results in FoxO phosphorylation, 14-3-3 binding and nuclear export (left). Cellular ROS stimulates JNK, which phosphorylates and activates FoxO, leading to its nuclear transport (right) [24]