Fig. 2
From: Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice
Bidirectional interaction between MSCs and MSC-surrounding dynamic microenvironment. a MSC-existing microenvironments in the recipients are composed of the diverse cellular subpopulations as well as the niche-associated stroma. Bidirectional interaction is noted between MSCs and MSCs’ microenvironment contents. b Allogeneic or autologous MSC transplant has been used for the treatment of diseases and conditions. Such MSCs in the transplanted tissue may be potentially impacted by the diverse pathological microenvironmental factors and, consequently, MSCs’ biological behaviors are probably altered in the recipients