Fig. 6From: Neuromedin B promotes chondrocyte differentiation of mesenchymal stromal cells via calcineurin and calcium signalingRole of NMB in calcium signaling. A Time course of maximal calcium intensity of spontaneous calcium oscillations in BM-MSCs transfected with siCT or siNMB and loaded with Fluo-4-AM at day 3 of chondrogenesis. B Calcium responsive rate determined in BM-MSCs transfected with siCT or siNMB at day 3 of chondrogenesis and expressed as fold change rate. C Intracellular calcineurin phosphatase activity determined in BM-MSCs transfected with siCT or siNMB at day 3 of chondrogenesis. D Fold change expression of SOX9 in BM-MSCs transfected with siCT or siNMB at day 3 of chondrogenesis. *: p ≤ 0.05, **: p ≤ 0.01Back to article page