Fig. 1

YAP upregulation is associated with a poor OS patient prognosis. a Overall survival (OS) outcomes for 26 and 27 patients expressing high and low levels of YAP, respectively. b YAP expression levels in 27 OS patient tissue samples and 40 normal patient muscle tissue samples (P < 0.001). c Bone tumor cell YAP expression was assessed using Cancer Cell Line Encyclopedia (CCLE) data. d YAP protein levels in bone tumor cells were assessed based upon CCLE data. e, f Western blotting was conducted to assess YAP levels in OS cell lines (HOS, MG63, U2OS, and SAOS2). g–i Western blotting and Immunohistochemical staining demonstrating YAP expression levels in human OS tumor cells and paracancerous tissues. Analyses were repeated in triplicate. *P < 0.05 **P < 0.01 ***P < 0.001