Fig. 5

Nuclear translocation of NF-κB p65 was inhibited by PI3K inhibition. A Western blotting analysis showed that treatment with LY294002 (30 µM, 50 µM) attenuated AKR1B10-induced Phosphorylated-PI3K, Phosphorylated-AKT; Phosphorylated-IKBα in MCF-7/AKR1B10 cells; B Western blotting analysis showed that treatment with LY294002 (30 µM, 50 µM) attenuated AKR1B10-incuded expression of nuclear NF-κB p65. Experiment was repeated three times. Representative results were presented. *P < 0.05