Fig. 2

SNHG1 acts an oncogene promoted tumorigenesis both in vitro and in vivo. a Expression of SNHG1 in MCF10A, Hs578T, MDA-MB-231, and MDA-MB-468 cell lines. b Transfection efficacy of siSNHG1 in MDA-MB-468, Hs578T, and MDA-MB-231 cells. c CCK-8 showed that silencing SNHG1 inhibited tumor cell proliferation. d Colony formation assay showed that silencing SNHG1 inhibited tumor cell clone formation. e Wound healing assay proved that silencing SNHG1 suppressed tumor cell migration. f Transwell invasion assay showed that knockdown of SNHG1 inhibited the invasion ability of tumor cells. g Knockdown efficacy of lentiviral targeting of snhg1. h CCK-8 showed that silencing of snhg1 suppressed 4T1 proliferation. i Tumor growth curve of mice shows that sh-snhg1#3 group had slower growth than that in the scramble group. j Tumor weight in the sh-snhg1#3 group was lower than that in the scramble group. k The tumorigenesis and tumor tissue of each group of Balb/C mice (N = 6 per group) are shown. l The survival of scramble and sh-snhg1#3 mice (N = 6 per group). Data are presented as the mean value from three independent experiments ± S.D. *P < 0.05; **P < 0.01; ***P < 0.001; *****P < 0.0001; NS no significance