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Table 1 Clinical characteristics of patients

From: Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Parameter Non drinker ALD    Non-pathological alcohol drinker controls  
Healthy control Alcoholic fatty liver disease Alcoholic cirrhosis Mixed cirrhosis Binge drinker HDC HBV liver cirrhosis
Number 116 4 48 33 34 11 7
Alcohol withdrawal (> 1 year) 0 23 33
Excessive drinks in the last 30d 10 0 34 11
Gender
Male (%)
93(80.2%) 3(75%) 47(97.9%) 33(100%) 19(55.9%) 11(100%) 7(100%)
Age(year) 48.89 ± 11.21 40.25 ± 3.30* 53.6 ± 15.62 52.21 ± 6.30 28.34 ± 9.59** 51.36 ± 10.62 51.86 ± 3.18
ALT(U/L) 26.3 ± 30.54 71 ± 28.57 40.4 ± 52.42 32.25 ± 17.73 24.4 ± 5.77 51.73 ± 89.31 28.71 ± 16.04
AST(U/L) 21.08 ± 11.43 49 ± 15.28 59.29 ± 64.85** 39.88 ± 19.14** 23.6 ± 5.18 24 ± 10.68 24.43 ± 9.03
TBIL (μmol/L) 13.76 ± 5.89 21.63 ± 15.26 44.34 ± 49.55** 21.54 ± 19.63 8.94 ± 4.68 16.56 ± 14.56 19.24 ± 7.79
ALB(g/L) 41.75 ± 3.38 37.08 ± 9.40 31.63 ± 4.86** 32.76 ± 6.45** 46.82 ± 4.03 39.24 ± 4.98 39 ± 1.53
ALP(U/L) 78.10 ± 20.21 86.25 ± 13.57 140.16 ± 54.89** 124.63 ± 49.86** 66.75 ± 15.59 78.73 ± 17.64 83.14 ± 13.06
GGT(U/L) 31.71 ± 47.43 143.75 ± 108.69 149.78 ± 170.36** 70.16 ± 59.74* 23.75 ± 10.99 49.64 ± 58.96 26.14 ± 24.65
PT(s) 11.70 ± 1.02 13.1 ± 0.95 15.80 ± 3.21 15.39 ± 3.16 11.95 ± 0.7 12.13 ± 0.8
WBC (× 109/L) 5.8 ± 1.59 7.87 ± 2.42 4.83 ± 2.22 4.0 ± 4.04 9.8 ± 3.64** 6.1 ± 0.73 4.99 ± 0.77
NEUT (%) 54.59 ± 7.57 71.45 ± 10.58 61.37 ± 15.98 58.73 ± 11.27 71.37 ± 12.45** 58.6 ± 8.64 53.03 ± 7.4
Neutrophil (× 109/L) 3.22 ± 1.21 5.75 ± 2.56 3.05 ± 1.91 2.47 ± 2.98 7.22 ± 3.52** 3.63 ± 0.86 2.94 ± 1.2
Lymphocyte (× 109/L) 2.37 ± 4.39 1.44 ± 0.51 1.18 ± 0.85 0.92 ± 0.81* 2.11 ± 0.99 1.87 ± 0.41 1.85 ± 0.39
  1. All values provided as mean ± SEM; P-valued were determined by the one-way ANOVA(LSD), or Welch’s ANOVA test (Games-Howell test)
  2. ALT alanine aminotransferase, AST aspartate transaminase, TBIL total bilirubin, GGT γ-glutamyl transferase, ALP alkaline phosphatase, ALB albumin, PT prothrombin time
  3. All healthy controls (HCs) (n = 116) must exclude drinking history. ALD patients include alcoholic fatty liver disease (AFL) (n = 4), alcoholic cirrhosis (n = 48). Non-pathological alcohol drinker controls include binge drinkers (n = 34) and heavy drinkers without overt clinical evidence of liver disease (HDC) (n = 11). Patients with chronic HBV infection (n = 7) and mixed cirrhosis (n=33) were HBV DNA-negative.
  4. *p < 0.05, **p < 0.01 (compared with blood from healthy individuals)