Human Diseases | m6A-associated factors | Autophagy-associated factors | Up/Down regulation of m6A methylation | Association between m6A modification and autophagy | Potential Mechanisms | References |
---|---|---|---|---|---|---|
Adipogenesis and Obesity | FTO | ATG5/ATG7 | Up | Negative | YTHDF2-dependent ATG5/ATG7 mRNA degradation | [18] |
Azoospermatism and oligo-spermatism | METTL14 /ALKBH5 | AMPK regulator (PPM1A/ CAMKK2) | Up | Negative | m6A modification reduced AMPK activity | [48] |
Ischemic heart disease | METTL3/ ALKBH5 | TFEB | Up | Negative | HNRNPD-dependent TFEB decreased expression | [17] |
IVD degeneration | ALKBH5 | FIP200 | Up | Negative | YTHDF2-mediated FIP200 mRNA degradation | [91] |
HCC | YTHDF1 | ATG2A/ATG14 | / | / | HIF-1α-induced YTHDF1 expression promotes ATG2A/ATG14 translation | [94] |
NSCLC | ALKBH5 | UBE2C/ATG3/LC3 | Down | Negative | ALKBH5 activated increases UBE2C-autophagy axis | [95] |
CRC | IGF2BP2 | Ubiquitin-autophagy pathway | / | / | IGF2BP2 increases MYC mRNA stability | [96] |
Melanoma | FTO | Metabolic starvation stress | Down | Induced | YTHDF2-mediated promotes melanoma tumorigenesis and anti-PD-1 resistance | [98] |
Drug resistance in NSCLC | METTL3 | ATG5/ATG7 | Up | Positive | METTL3 positively regulated autophagy in gefitinib resistance | [19] |
Drug resistance in HCC | METTL3 | ATG5/ATG7/ ATG16L1 | Down | Negative | METTL3-mediated FOXO3 mRNA stabilization and negative impact on ATG proteins in sorafenib resistance | [51] |
Drug resistance in CGC | METTL3 | SQSTM1 | Up | Negative | Impaired autophagic degradation of lncRNA stabilizes ARHGAP5 mRNA via facilitating METTL3 in chemoresistance | [99] |