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Table 1 m6A and autophagy associated factors involved in m6A-autophagy interaction and their potential mechanisms in human diseases

From: Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

m6A-associated factors Autophagy-associated factors Up/Down regulation of m6A methylation Association between m6A modification and autophagy Potential Mechanisms References
Adipogenesis and Obesity FTO ATG5/ATG7 Up Negative YTHDF2-dependent ATG5/ATG7
mRNA degradation
Azoospermatism and oligo-spermatism METTL14
AMPK regulator
Up Negative m6A modification reduced AMPK activity [48]
Ischemic heart disease METTL3/ ALKBH5 TFEB Up Negative HNRNPD-dependent TFEB decreased expression [17]
IVD degeneration ALKBH5 FIP200 Up Negative YTHDF2-mediated FIP200 mRNA degradation [91]
HCC YTHDF1 ATG2A/ATG14 / / HIF-1α-induced YTHDF1 expression promotes ATG2A/ATG14 translation [94]
NSCLC ALKBH5 UBE2C/ATG3/LC3 Down Negative ALKBH5 activated increases UBE2C-autophagy axis [95]
CRC IGF2BP2 Ubiquitin-autophagy pathway / / IGF2BP2 increases MYC mRNA stability [96]
Melanoma FTO Metabolic starvation stress Down Induced YTHDF2-mediated promotes melanoma tumorigenesis and anti-PD-1 resistance [98]
Drug resistance in NSCLC METTL3 ATG5/ATG7 Up Positive METTL3 positively regulated autophagy in gefitinib resistance [19]
Drug resistance in HCC METTL3 ATG5/ATG7/
Down Negative METTL3-mediated FOXO3 mRNA stabilization and negative impact on ATG proteins in sorafenib resistance [51]
Drug resistance in CGC METTL3 SQSTM1 Up Negative Impaired autophagic degradation of lncRNA stabilizes ARHGAP5 mRNA via facilitating METTL3 in chemoresistance [99]
  1. IVD Intervertebral disc, HCC hepatocellular carcinoma, NSCLC non-small cell lung cancer, CRC colorectal cancer, CGC chemoresistant gastric cancer