Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Cell & Bioscience

Table 1 m6A and autophagy associated factors involved in m6A-autophagy interaction and their potential mechanisms in human diseases

Human Diseases	m6A-associated factors	Autophagy-associated factors	Up/Down regulation of m6A methylation	Association between m6A modification and autophagy	Potential Mechanisms	References
Adipogenesis and Obesity	FTO	ATG5/ATG7	Up	Negative	YTHDF2-dependent ATG5/ATG7 mRNA degradation	[18]
Azoospermatism and oligo-spermatism	METTL14 /ALKBH5	AMPK regulator (PPM1A/ CAMKK2)	Up	Negative	m6A modification reduced AMPK activity	[48]
Ischemic heart disease	METTL3/ ALKBH5	TFEB	Up	Negative	HNRNPD-dependent TFEB decreased expression	[17]
IVD degeneration	ALKBH5	FIP200	Up	Negative	YTHDF2-mediated FIP200 mRNA degradation	[91]
HCC	YTHDF1	ATG2A/ATG14	/	/	HIF-1α-induced YTHDF1 expression promotes ATG2A/ATG14 translation	[94]
NSCLC	ALKBH5	UBE2C/ATG3/LC3	Down	Negative	ALKBH5 activated increases UBE2C-autophagy axis	[95]
CRC	IGF2BP2	Ubiquitin-autophagy pathway	/	/	IGF2BP2 increases MYC mRNA stability	[96]
Melanoma	FTO	Metabolic starvation stress	Down	Induced	YTHDF2-mediated promotes melanoma tumorigenesis and anti-PD-1 resistance	[98]
Drug resistance in NSCLC	METTL3	ATG5/ATG7	Up	Positive	METTL3 positively regulated autophagy in gefitinib resistance	[19]
Drug resistance in HCC	METTL3	ATG5/ATG7/ ATG16L1	Down	Negative	METTL3-mediated FOXO3 mRNA stabilization and negative impact on ATG proteins in sorafenib resistance	[51]
Drug resistance in CGC	METTL3	SQSTM1	Up	Negative	Impaired autophagic degradation of lncRNA stabilizes ARHGAP5 mRNA via facilitating METTL3 in chemoresistance	[99]

IVD Intervertebral disc, HCC hepatocellular carcinoma, NSCLC non-small cell lung cancer, CRC colorectal cancer, CGC chemoresistant gastric cancer

ISSN: 2045-3701