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Fig. 3 | Cell & Bioscience

Fig. 3

From: Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Fig. 3

Effects of m6A-autophagy interaction in metabolic related diseases. A FTO-mediated demethylation provides stability to ATG5 and ATG7 transcripts. Subsequently, autophagy is induced, which promotes adipogenesis and obesity. B m6A mediated reduction in AMPK (AMP-activated protein kinase) activity resulted in autophagy inhibition. Consequently, testosterone synthesis decreased, which mediated azoospermtism or oligospermatism

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