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Table 1 Comparison of the expression of select innate immune genes in the IFN signaling pathway in the lungs and spleen between B6 and D2 mice

From: Differing susceptibility of C57BL/6J and DBA/2J mice—parents of the murine BXD family, to severe acute respiratory syndrome coronavirus infection

Gene ID

Gene symbol

Description

Log2 diff. in lungs (B6-D2)

Log2 diff. in spleen (B6-D2)

230073

Ddx58

DExD/H-box helicase 58

− 0.066

0.438

71586

Ifih1

Interferon induced with helicase C domain 1

− 0.058

0.411

142980

Tlr3

Toll-like receptor 3

− 0.390

0.358

228607

D430028G21Rik

Mitochondrial antiviral signaling protein

0.161

− 0.094

106759

Ticam1

Toll-like receptor adaptor molecule 1

0.153

0.008

54131

Irf3

Interferon regulatory factor 3

− 0.062

0.089

54123

Irf7

Interferon regulatory factor 7

− 0.205

0.007

15975

Ifnar1

Interferon (alpha and beta) receptor 1

− 0.088

0.044

242700

Il28ra

Interleukin-28 receptor subunit alpha

− 0.162

− 0.021

20846

Stat1

Signal transducer and activator of transcription 1

− 0.457

0.256

20847

Stat2

Signal transducer and activator of transcription 2

− 0.212

− 0.553

  1. None of the genes listed herein showed a difference in mRNA expression of ≥ 1.5-fold (i.e., 0.58 in Log2) between B6 and D2 mice in the lungs or spleen. D430028G21Rik is also known as Mavs; Il28ra is also known as Ifnlr1; Ticam1 is also known as Trif