Table 1 Statistically significant associations for mCAs and incident disease associations.
mCA | Disease | N | Percent with preceding cancer | Odds ratio [95% Confidence Interval] | P-value |
|---|---|---|---|---|---|
Autosome | C91 Lymphoid leukaemia | 616 | 35.47 | 23.74 [20.21–27.88] | < 5 × 10–324 |
Autosome | D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue | 729 | 37.5 | 5.29 [4.38–6.39] | 1.97 × 10–67 |
Autosome | C83 Diffuse non-Hodgkin's lymphoma | 903 | 50.67 | 4.62 [3.88–5.5] | 9.64 × 10–66 |
Autosome | D45 Polycythaemia vera | 201 | 21.47 | 12.26 [9.1–16.51] | 3.37 × 10–61 |
Autosome | C85 Other and unspecified types of non-Hodgkin's lymphoma | 859 | 59.02 | 4.28 [3.56–5.15] | 1.27 × 10–53 |
Autosome | D70 Agranulocytosis | 4637 | 72.65 | 2.24 [2.02–2.49] | 9.73 × 10–51 |
Autosome | D46 Myelodysplastic syndromes | 302 | 47.86 | 6.19 [4.72–8.13] | 1.65 × 10–39 |
Autosome | C92 Myeloid leukaemia | 381 | 47.22 | 5.19 [4–6.73] | 1.66 × 10–35 |
Autosome | R16 Hepatomegaly and splenomegaly, not elsewhere classified | 611 | 36.33 | 3.78 [2.99–4.77] | 9.44 × 10–29 |
Autosome | D69 Purpura and other haemorrhagic conditions | 3090 | 38.04 | 2.01 [1.76–2.29] | 2.02 × 10–25 |
Autosome | A41 Other septicaemia | 10,144 | 52.41 | 1.54 [1.42–1.67] | 2.43 × 10–25 |
Autosome | D80 Immunodeficiency with predominantly antibody defects | 248 | 42.63 | 5.44 [3.91–7.56] | 7.27 × 10–24 |
Autosome | D75 Other diseases of blood and blood-forming organs | 1059 | 25.52 | 2.77 [2.27–3.38] | 9.33 × 10–24 |
Autosome | C95 Leukaemia of unspecified cell type | 50 | 76.92 | 13.37 [7.43–24.06] | 4.92 × 10–18 |
Autosome | D72 Other disorders of white blood cells | 794 | 27.25 | 2.66 [2.1–3.36] | 2.97 × 10–16 |
Autosome | J18 Pneumonia, organism unspecified | 17,638 | 29.62 | 1.32 [1.24–1.41] | 3.19 × 10–16 |
Autosome | C94 Other leukaemias of specified cell type | 32 | 70.59 | 14.93 [7.2–30.96] | 3.73 × 10–13 |
Autosome | D61 Other aplastic anaemias | 879 | 46.57 | 2.24 [1.78–2.82] | 6.94 × 10–12 |
Autosome | Z51 Other medical care | 23,428 | 63.39 | 1.24 [1.16–1.32] | 1.38 × 10–11 |
Autosome | C84 Peripheral and cutaneous T-cell lymphomas | 154 | 41.08 | 4.37 [2.83–6.72] | 2.27 × 10–11 |
Autosome | C93 Monocytic leukaemia | 51 | 80.77 | 6.61 [3.5–12.47] | 5.89 × 10–9 |
Autosome | J90 Pleural effusion, not elsewhere classified | 10,097 | 42.9 | 1.29 [1.18–1.41] | 1.06 × 10–8 |
Autosome | C88 Malignant immunoproliferative diseases | 121 | 69.7 | 4.17 [2.55–6.83] | 1.43 × 10–8 |
Autosome | C82 Follicular [nodular] non-Hodgkin's lymphoma | 347 | 37.96 | 2.71 [1.91–3.83] | 1.94 × 10–8 |
Autosome | Z85 Personal history of malignant neoplasm | 20,384 | 88.65 | 1.21 [1.13–1.29] | 1.98 × 10–8 |
Autosome | J98 Other respiratory disorders | 12,465 | 29.57 | 1.26 [1.16–1.37] | 4.06 × 10–8 |
Autosome | Y43 Primarily systemic agents | 2494 | 93.78 | 1.58 [1.34–1.86] | 5.24 × 10–8 |
Autosome | B25 Cytomegaloviral disease | 171 | 51.13 | 3.63 [2.27–5.81] | 7.78 × 10–8 |
Autosome | N17 Acute renal failure | 14,465 | 42.7 | 1.22 [1.13–1.32] | 1.61 × 10–7 |
Autosome | E87 Other disorders of fluid, electrolyte and acid–base balance | 15,028 | 38.77 | 1.22 [1.13–1.31] | 2.40 × 10–7 |
Autosome | D64 Other anaemias | 16,970 | 30.46 | 1.2 [1.11–1.29] | 9.06 × 10–7 |
Autosome | Z94 Transplanted organ and tissue status | 724 | 44.28 | 1.99 [1.5–2.65] | 1.94 × 10–6 |
Autosome | D59 Acquired haemolytic anaemia | 177 | 38.52 | 2.96 [1.85–4.73] | 5.70 × 10–6 |
Autosome | R50 Fever of unknown origin | 3504 | 48.62 | 1.4 [1.21–1.63] | 6.79 × 10–6 |
Autosome | B96 Other bacterial agents as the cause of diseases classified to other chapters | 9917 | 33.45 | 1.23 [1.12–1.35] | 8.21 × 10–6 |
Autosome | R60 Oedema, not elsewhere classified | 2075 | 42.78 | 1.49 [1.25–1.78] | 1.11 × 10–5 |
Autosome | E83 Disorders of mineral metabolism | 5293 | 43.15 | 1.3 [1.15–1.47] | 2.23 × 10–5 |
Autosome | R22 Localised swelling, mass and lump of skin and subcutaneous tissue | 1175 | 28.16 | 1.66 [1.31–2.11] | 2.82 × 10–5 |
Autosome | G72 Other myopathies | 258 | 28.99 | 2.45 [1.6–3.74] | 3.29 × 10–5 |
Autosome | T86 Failure and rejection of transplanted organs and tissues | 232 | 49.76 | 2.6 [1.65–4.08] | 3.39 × 10–5 |
mLOX | C91 Lymphoid leukaemia | 236 | 35.47 | 2.45 [1.7–3.53] | 1.40 × 10–6 |
mLOX | J03 Acute tonsillitis | 1167 | 4.97 | 1.78 [1.39–2.27] | 4.85 × 10–6 |
mLOY | E11 Non-insulin-dependent diabetes mellitus | 14,110 | 21.37 | 0.8 [0.77–0.84] | 3.67 × 10–22 |
mLOY | I10 Essential (primary) hypertension | 46,694 | 20.37 | 0.91 [0.89–0.94] | 2.91 × 10–11 |
mLOY | H36 Retinal disorders in diseases classified elsewhere | 1359 | 20.69 | 0.65 [0.56–0.75] | 1.46 × 10–9 |
mLOY | E66 Obesity | 12,647 | 22.40 | 0.87 [0.83–0.91] | 1.12 × 10–8 |
mLOY | E14 Unspecified diabetes mellitus | 1642 | 11.07 | 0.7 [0.61–0.8] | 9.34 × 10–8 |
mLOY | M10 Gout | 5601 | 14.55 | 0.87 [0.81–0.93] | 3.74 × 10–5 |
mLOY | E16 Other disorders of pancreatic internal secretion | 1641 | 30.03 | 0.78 [0.69–0.88] | 4.28 × 10–5 |
mLOY | G63 Polyneuropathy in diseases classified elsewhere | 646 | 29.78 | 0.65 [0.53–0.8] | 4.29 × 10–5 |