Fig. 2
From: SARS-CoV-2: from its discovery to genome structure, transcription, and replication
Coronavirus genome replication and transcription. Diagram showing the key steps in coronavirus entry (1), initial translation of incoming viral +gRNA to express viral non-structural proteins (nsp1-16) (2), genome replication in double-membrane vesicles (DMVs), continuous transcription of gRNA through a −gRNA-intermediate by viral replication and transcription complex (RTC) (3), generation of sgRNA by discontinuous transcription RTC (4), the expression of structural and accessory proteins from +sgRNA (S, spike; M, membrane; E, envelope; N proteins) (5), and virion assembly and release (6)