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Fig. 2 | Cell & Bioscience

Fig. 2

From: Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity

Fig. 2

Subclusters and pseudotime trajectory of FBs in endometriosis lesions, eutopic endometrium and normal endometrium. A Differential expression analysis of FBs genes was performed comparing FBs from endometriosis lesions, eutopic endometrium and normal endometrium. Heatmaps are shown representing upregulated and downregulated genes. The full table of genes is shown in Additional file 11. B FBs on the t-SNE plot of all nine samples are coloured as originating either from patients with endometriosis or without endometriosis. C Functional enrichment analysis with GO and KEGG was performed with significantly upregulated genes in each group. Representative significantly enriched function processes are shown. D, E Monocle analyses showing the development of FBs along the pseudotime trajectory. F Heatmap of different blocks of DEGs along the pseudotime trajectory. The full table of DEGs is shown in Additional file 5. Functional enrichment analysis with GO and KEGG analysis was performed with the enriched genes in cells from fates 1 and 2

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