Table 1 The databases of ligand-receptor pairs
Database | Ligand-receptor complexs | Level | Species | Pairs number | Verified | Address | Author |
|---|---|---|---|---|---|---|---|
Yes | Protein | Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Caenorhabditis elegans, Helicobacter pylori, Bos taurus, Arabidopsis thaliana | 81,923 | Yes | Lukasz Salwinski et al. | ||
Database of ligand-receptor partners (DLRP) [20] | No | Protein | NA | NA | Yes | NA | Graeber et al. |
Human plasma membrane receptome (HPMR) database [21] | No | Protein | Homo sapiens | NA | Yes | Izhar Ben-Shlomo et al. | |
The Online Predicted Human Interaction Database (OPHID) [22] | Yes | Protein | Homo sapiens,Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Mus musculus | 23,889 | Part | http:Â //ophid.utoronto.ca | Kevin R Brown et al. |
Mother Of All Databases (Binding MOAD) [23] | Yes | Protein | NA | 38,702 | Yes | Liegi Hu et al. | |
Unified Human Interactome database (UniHI) [24] | No | Protein | Homo sapiens | 150,000 | Part | Gautam Chaurasia et al. | |
Interolog interaction database (I2D) [25] | No | Protein | Homo sapiens,Saccharomyces cerevisiae, Caenorhabditis elegans, Rattus norvegicus, Drosophila melanogaster and Mus musculus | 1,279,157 | Part | Kevin R Brown et al. | |
GPCR-Ligand Database (GLIDA) [26] | Yes | Protein | NA | 39,140 | Yes | Yasushi Okuno et al. | |
No | Protein and gene | Homo sapiens | 215 541 | Part | Atanas Kamburov et al. | ||
The International Union of Basic and Clinical Pharmacology database (IUPHAR-DB) [30, 31] | Yes | Protein and gene | Homo sapiens | 48,902 | Part | Sharman et al. | |
The molecular interaction database (MINT) [32] | No | Protein | NA | 235,000 | Part | Luana Licata et al. | |
InnateDB [33] | No | Protein and gene | Homo sapiens, Mus musculus and Bos taurus | 18,780 | Yes | Karin Breuer et al. | |
No | Protein | 5090 organisms | 3,123,056,667 | Part | Izhar Ben-Shlomo et al. | ||
The TissueNet database [36] | No | Protein | Homo sapiens | NA | Part | Ruth Barshir et al. | |
The Transformer database [37] | Yes | Protein | NA | NA | Yes | Michael F Hoffmann et al. | |
IntAct [38] | No | Protein and gene | Multiple organisms | NA | Part | Sandra Orchard | |
The extracellular matrix interaction database (MatrixDB) [39] | No | Protein | Multiple organisms | 106,543 | Yes | G Launay et al. | |
A draft network of ligand-receptor-mediated [40] | No | Protein and gene | Homo sapiens | 2950 | Part | Ramilowski et al. | |
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) [41] | Yes | Protein | Multiple organisms | NA | Part | Peter W Rose et al. | |
The DifferentialNet database [42] | No | Protein | Homo sapiens | NA | No | Omer Basha et al. | |
Protein–Protein Interaction Sitesbase (PPInS) [43] | Yes | Protein | NA | 32,468 | Part | Vicky Kumar et al. | |
UniLectin3D [44] | Yes | Protein | NA | NA | Part | François Bonnardel et al. | |
Ligand/Receptor Interaction Database (LRdb) [45] | No | Protein and gene | Homo sapiens | 3085 | Yes | Simon Cabello-Aguilar et al. | |
CellPhoneDB [46] | Yes | Protein and gene | Homo sapiens | 1396 | Part | Mirjana Efremova et al. | |
CellTalk Database (CellTalkDB) [47] | No | Protein | Homo sapiens, Mouse | 5431 | Yes | Xin Shao et al. |