Fig. 5

Effect of FTVII-modified BMSCs on the ENS remodeling in diabetic mice. A Representative immunofluorescence confocal laser images in transverse sections of colon tissue sections of PGP9.5(green) in each group; the nuclei (blue). B Representative immunofluorescence confocal laser images in transverse sections of colon tissue sections of GFAP (green) in each group; the nuclei (blue); C Representative immunofluorescence confocal laser images in colon myenteric plexus of PGP9.5 (green) in each group. D Representative immunofluorescence confocal laser images in colon myenteric plexus of GFAP (green) in each group. E The protein expression of PGP9.5 in the colon tissues was examined by immunoblotting. F The statistics results of PGP9.5 protein expression in the colon tissues. G The protein expression of GFAP in the colon tissues was examined by immunoblotting. H The statistics results of GFAP protein expression in the colon tissues. Control: the control C57 mice; DM: diabetic mice; DM + BMSCs: diabetic mice injected with unmodified BMSCs; DM + F-BMSCs: diabetic mice injected with FTVII-modified BMSCs. These results are representative of at least three times independent experiments. Results were expressed as mean ± SD,*P < 0.05,**P < 0.01, ***P < 0.001, ****P < 0.001, NS no significance