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Table 1 Dysregulation of miRNAs in PNI of tumor

From: MicroRNAs: emerging driver of cancer perineural invasion

Cancer type

miRNA

Regulation

Target

References

Pancreatic cancer

miR-429

Downregulated

NT-3

[14]

miR-191

Upregulated

HRE2

[45, 84]

miR-21, miR-23a/miR-27a

Upregulated

PDCD、BTG2、NEDD4L

[46]

miR-17

Upregulated

PTEN

[63]

miR-133a

Downregulated

EGFR

[99]

miR-216

Downregulated

YB-1

[122]

Cholangiocarcinoma

miR-21

Upregulated

RECK

[47]

miR-31

Downregulated

BAP-1, PBRM-1

[95]

miR-204

Downregulated

CXCR4

[114]

Gastric cancer

miR-589-3p, miR-141

Upregulated

circ_0000419

[89]

Colorectal cancer

miR-128-3p

Upregulated

Foxo4

[85]

miR-3679-5p

Upregulated

 

[86]

Prostate cancer

miR-21, miR-99b/miR100, miR-24-2/miR-27a, miR-15a-2/ miR-195, miR-224, miR-10 (a/b), miR-125b (− 1/2), miR-30a/b/c-2, miR-26a (− 1/2), miR-126, miR-145, miR-151, miR-181a-1, let-7g

Upregulated

metallothionein

[45]

miR-191

Upregulated

HRE2

[84]

miR-124-3p

Downregulated

SARM1

[118]

HNSCC

miR-137

Downregulated

 

[117]

let-7d

Upregulated

 

[135]

OSCC

miR-21

Upregulated

PTEN

[15]

miR-370

Downregulated

IRS-1

[115]

miR-7

Downregulated

RAF-1

[116]

let-7a

Downregulated

 

[134]

Sinonasal SCC

miR-9-3p

Upregulated

 

[87]

Cutaneous SCC

miR-205

Upregulated

 

[88]