Table 1 Role of microbubbles in different diseases and in different clinical trials
From: Artificial intelligence and guidance of medicine in the bubble
S. No | Name | Type | Disease type | Role | Technology | Clinical trials |
|---|---|---|---|---|---|---|
1 | The Role of Different Imaging Methods in the Diagnosis of Gallbladder Polyps | Interventional | Polyp of Gallbladder | Preoperative differential diagnostic accuracies of gallbladder polypoid lesions | Device: Abdominal high-resolution CT Device: Contrast-enhanced ultrasonography Procedure: Cholecystectomy | NCT02762227 |
2 | Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients with Chest-wall and Locally-Advanced Breast Cancer | Interventional | Breast Cancer | Novel MRI-guided ultrasound stimulated microbubble treatment enhances radiation effects in humans receiving external beam radiotherapy delivered using radiation therapy device | Patients with locally advanced breast cancer and chest wall tumours will receive MRI-guided ultrasound-stimulated microbubble-treatment combined with radiotherapy | NCT04431674 |
3 | The Use of Focused Ultrasound and Microbubble Infusion for Altering Brain Perfusion and the Blood Brain Barrier | Interventional | Low Grade Glioma of Brain | The ability of focused ultrasound combined with microbubbles to open the blood brain barrier has the potential to revolutionize the delivery of therapeutic agents to the brain, allowing for more localized and efficient delivery | The ultrasound treatment will last either 1Â h or 20Â min total time for the DWL device. An infusion of Definity microbubbles will be infused intravenously over ten to thirty minutes as per routine approved application. Definity will be 1.3Â mL added to 50Â mL saline and infused no faster than 4Â mL/minute | NCT04063514 |
4 | Microbubbles and Ultrasound in Stroke Trial | Interventional | Acute Ischemic Stroke | Transcranial 2-MHz ultrasound combined with intravenous administration of microbubbles improves early recanalization in patients with acute ischemic stroke caused by middle cerebral artery proximal occlusion treated with intravenous alteplase within 3Â h of symptom onset | Radiation: Ultrasound 2-MHz, low intensity transcranial ultrasound Drug: Levovist D-Galactose and palmitic palmitique intravenous 4Â g | NCT00222040 |
5 | Microbubble Cavitation for Improving Hepatocellular Carcinoma Radioembolization | Interventional | Hepatocellular Carcinoma Liver Cancer | Localized microbubble cavitation triggered by noninvasive ultrasound has been shown to sensitize malignant tissue to radiotherapy by inducing vascular endothelial cell apoptosis | Patients receive perflutren protein-type A microspheres IV over 10 min and undergo CEUS over 60 min at 1–6 h post radioembolization and at approximately 7 and 14 days after yttrium Y-90 radioembolization | NCT03199274 |
6 | Targeted Delivery of Chemotherapy with Ultrasound and Microbubbles (SONCHIMIO) | Interventional | Colorectal Cancer Hepatic Metastases | The oscillations of ultrasound (US) contrast agent microbubbles under their activation by US waves engender a modulation of the permeability of biological barriers amplifying hence the extravasation of drugs/fluorescent markers through a process known as sonoporation | Liver metastases randomized to receive sonoporation (US waves + gaseous microbubbles). The patient continues to receive the usual systemic chemotherapy | NCT03458975 |