Emerging roles of non-histone protein crotonylation in biomedicine

Cell & Bioscience

Table 2 Different classes of lysine decrotonylases, their co-factors, cellular locations, and substrates

Co-factor	Class	Members	Location	Histone	Substrate
Co-factor	Class	Members	Location	Histone	References	Non-histone	References
Zn²⁺-dependent	HDAC I	HDAC1	Nucleus	H3K4, H3K9, H3K18, H3K23, H4K8, and H4K12	[36]	NPM1	[17]
		HDAC2	Nucleus	H3K9, H3K18, and H4K8	[36]	N/A	N/A
		HDAC3	Nucleus	H3K9, H3K18, and H4K8	[36]	NPM1	[17]
		HDAC8	Nucleus	H3K4, H3K9, H3K18, H4K8, and H4K12	[36]	N/A	N/A
NAD⁺-dependent	HDAC III	SIRT1	Nucleus/ cytoplasm	H3K4, H3K9, and H4K8	[36,37,38]	N/A	N/A
		SIRT2	cytoplasm	H3K4 and H3K9	[37, 38]	N/A	N/A
		SIRT3	Mitochondria	H3K4	[38]	N/A	N/A

ISSN: 2045-3701