Fig. 4From: Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expressionSPD improves aging of FGSC depending on upregulation of p62. Protein expression of p16 and p53 in p62-kd and control-kd FGSCs with or without SPD treatment after induction by H2O2. Data are representative of at least three independent experiments. *P < 0.05, * P < 0.01, and ***P < 0.001 compared with controls. n.s. no significance, kd knockdown, Con controlBack to article page