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Fig. 4 | Cell & Bioscience

Fig. 4

From: CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma

Fig. 4

CpG-ODN and BUD synergistically affect RORγt expression in CS-exposed asthmatic mice. Representative photomicrographs of immunohistochemical staining of lung sections for RORγt from various animal groups (×200) (a). RORγt-positivity rate was determined as RORγt-positive area/total bronchiole area (b). The mRNA expression levels of RORγt were determined by qRT-PCR in lung tissue samples from mice (c). Immunoblot was carried out for assessing RORγt protein levels in lung tissue samples, with GAPDH as a loading control; RORγt/GAPDH ratios were determined (d, e). Statistical significance denoted:*, #p < 0.05, **,##p < 0.01. *versus the vehicle control group; # versus the indicated group

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Cell & Bioscience

ISSN: 2045-3701

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