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Table 1. E3 ubiquitin ligases and deubiquitinases found to be significantly altered in response to HBV integration

From: Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line

Protein accession Protein description Gene name L/H ratio Regulated type
E3 ubiquitin ligases
 O00257 E3 SUMO-protein ligase CBX4 CBX4 4.756 Up
 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 0.425 Down
 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 0.480 Down
 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 0.232 Down
 Q13356 Peptidyl-prolyl cis–trans isomerase-like 2 PPIL2 2.341 Up
 O95155 Ubiquitin conjugation factor E4 B UBE4B 0.421 Down
 Q15386 Ubiquitin-protein ligase E3C UBE3C 0.337 Down
 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 0.422 Down
 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 0.357 Down
 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 0.479 Down
 Q13616 Cullin-1 CUL1 0.410 Down
 Q13619 Cullin-4A CUL4A 0.267 Down
 Q16773 Kynurenine–oxoglutarate transaminase 1 CCBL1 0.319 Down
 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 0.476 Down
 Q14527 Helicase-like transcription factor HLTF 0.200 Down
 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 2.531 Up
 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 2.016 Up
 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 2.189 Up
 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 0.270 Down
 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 0.454 Down
 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 2.062 Up
 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 2.531 Up
 O15164 Transcription intermediary factor 1-alpha TRIM24 2.562 Up
 P14373 Zinc finger protein RFP TRIM27 2.065 Up
 Q12899 Tripartite motif-containing protein 26 TRIM26 0.473 Down
 Q14134 Tripartite motif-containing protein 29 TRIM29 0.072 Down
 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 2.457 Up
 Q6PID6 Tetratricopeptide repeat protein 33 TTC33 0.440 Down
Deubiquitinases
 P51784 Ubiquitin carboxyl-terminal hydrolase 11 USP11 3.239 Up
 Q9P275 Ubiquitin carboxyl-terminal hydrolase 36 USP36 2.158 Up
 Q86UV5 Ubiquitin carboxyl-terminal hydrolase 48 USP48 0.284 Down
 Q96RU2 Ubiquitin carboxyl-terminal hydrolase 28 USP28 0.299 Down
 Q99956 Dual specificity protein phosphatase 9 DUSP9 4.069 Up
 O75319 RNA/RNP complex-1-interacting phosphatase DUSP11 2.974 Up
 Q96BN8 Ubiquitin thioesterase otulin OTULIN 0.411 Down