Table 1. E3 ubiquitin ligases and deubiquitinases found to be significantly altered in response to HBV integration
Protein accession | Protein description | Gene name | L/H ratio | Regulated type |
|---|---|---|---|---|
E3 ubiquitin ligases | ||||
 O00257 | E3 SUMO-protein ligase CBX4 | CBX4 | 4.756 | Up |
 O95714 | E3 ubiquitin-protein ligase HERC2 | HERC2 | 0.425 | Down |
 Q5GLZ8 | Probable E3 ubiquitin-protein ligase HERC4 | HERC4 | 0.480 | Down |
 Q7Z6Z7 | E3 ubiquitin-protein ligase HUWE1 | HUWE1 | 0.232 | Down |
 Q13356 | Peptidyl-prolyl cis–trans isomerase-like 2 | PPIL2 | 2.341 | Up |
 O95155 | Ubiquitin conjugation factor E4 B | UBE4B | 0.421 | Down |
 Q15386 | Ubiquitin-protein ligase E3C | UBE3C | 0.337 | Down |
 Q8IWV7 | E3 ubiquitin-protein ligase UBR1 | UBR1 | 0.422 | Down |
 O95071 | E3 ubiquitin-protein ligase UBR5 | UBR5 | 0.357 | Down |
 Q8N806 | Putative E3 ubiquitin-protein ligase UBR7 | UBR7 | 0.479 | Down |
 Q13616 | Cullin-1 | CUL1 | 0.410 | Down |
 Q13619 | Cullin-4A | CUL4A | 0.267 | Down |
 Q16773 | Kynurenine–oxoglutarate transaminase 1 | CCBL1 | 0.319 | Down |
 Q9Y4X5 | E3 ubiquitin-protein ligase ARIH1 | ARIH1 | 0.476 | Down |
 Q14527 | Helicase-like transcription factor | HLTF | 0.200 | Down |
 Q8IU81 | Interferon regulatory factor 2-binding protein 1 | IRF2BP1 | 2.531 | Up |
 Q7Z5L9 | Interferon regulatory factor 2-binding protein 2 | IRF2BP2 | 2.016 | Up |
 Q9NX47 | E3 ubiquitin-protein ligase MARCH5 | MARCH5 | 2.189 | Up |
 O75592 | E3 ubiquitin-protein ligase MYCBP2 | MYCBP2 | 0.270 | Down |
 Q9Y314 | Nitric oxide synthase-interacting protein | NOSIP | 0.454 | Down |
 Q9BYM8 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | RBCK1 | 2.062 | Up |
 Q99496 | E3 ubiquitin-protein ligase RING2 | RNF2 | 2.531 | Up |
 O15164 | Transcription intermediary factor 1-alpha | TRIM24 | 2.562 | Up |
 P14373 | Zinc finger protein RFP | TRIM27 | 2.065 | Up |
 Q12899 | Tripartite motif-containing protein 26 | TRIM26 | 0.473 | Down |
 Q14134 | Tripartite motif-containing protein 29 | TRIM29 | 0.072 | Down |
 Q13049 | E3 ubiquitin-protein ligase TRIM32 | TRIM32 | 2.457 | Up |
 Q6PID6 | Tetratricopeptide repeat protein 33 | TTC33 | 0.440 | Down |
Deubiquitinases | ||||
 P51784 | Ubiquitin carboxyl-terminal hydrolase 11 | USP11 | 3.239 | Up |
 Q9P275 | Ubiquitin carboxyl-terminal hydrolase 36 | USP36 | 2.158 | Up |
 Q86UV5 | Ubiquitin carboxyl-terminal hydrolase 48 | USP48 | 0.284 | Down |
 Q96RU2 | Ubiquitin carboxyl-terminal hydrolase 28 | USP28 | 0.299 | Down |
 Q99956 | Dual specificity protein phosphatase 9 | DUSP9 | 4.069 | Up |
 O75319 | RNA/RNP complex-1-interacting phosphatase | DUSP11 | 2.974 | Up |
 Q96BN8 | Ubiquitin thioesterase otulin | OTULIN | 0.411 | Down |