Fig. 3

Adiponectin signaling in Cardiomyocyte. Adiponectin-induced activation of AdipoR1 or AdipoR2, triggers LKB1-mediated activation of AMPK that prevents cardiac hypertrophy by inhibiting Nuclear factor-κB (NF-ĸB), reactive oxygen species (ROS) formation and extracellular signal-regulated kinase (ERK) and by stimulating fatty acid oxidation. Adiponectin-induced AMPK also prevents inflammation-mediated myocardial infarction through the activation of endothelial nitric oxide synthase (eNOS) as well as prevents diabetic cardiomyopathy via increasing fatty acid oxidation. Adiponectin-induced activation of ceramidase (CDase) prevents apoptosis of cardiomyocytes and subsequent development of cardiac hypertrophy through the degradation of ceramides. Activated AdipoR1/AdipoR2 prevents diabetic cardiomyopathy through APPL1-Rho-ROCK-mediated elevation of glucose uptake. Adiponectin-induced activation of Sphk-1-COX-2 cascade prevents myocardial infarction through the inhibition of TNF-α-mediated inflammation. Adiponectin-induced activation of PPARγ increases the transcription of adiponectin in cardiomyocytes