Table 1 The roles of different m6A regulators in CRC
m6A regulators | Genes | Location | Role | Mechanism | Function | Refs |
|---|---|---|---|---|---|---|
Writers | ||||||
 METTL3 | SOX2 | mRNA | Oncogene | Stabilize SOX2 mRNA | Promoting CRC tumorigenesis and metastasis | [60] |
MYC | mRNA | Oncogene | Enhance expression of MYC | Promoting CC cells proliferation | [61] | |
CCNE1 | mRNA | Oncogene | Stabilize CCNE1 mRNA | Promoting CRC cells proliferation | [62] | |
HK2/GLUT1 | mRNA | Oncogene | Stabilize HK2 and GLUT1 mRNA | Promoting CRC tumorigenesis | [63] | |
GLUT1 | mRNA | Oncogene | Promote GLUT1 mRNA translation | Promoting CRC development | [64] | |
CBX8 | mRNA | Oncogene | Stabilize CBX8 mRNA | Promoting CC stemness and chemoresistance | [65] | |
SOCS2 | mRNA | Oncogene | Degrade SOCS2 mRNA | Promoting CC cells proliferation | [66] | |
HSF1 | mRNA | Oncogene | Promote HSF1 mRNA translation | Promoting CRC development | [67] | |
RP11 | lncRNA | Oncogene | Promote the nuclear accumulation of RP11 | Promoting CRC cells migration | [68] | |
miR-1246 | miRNA | Oncogene | Promote miR-1246 maturation | Promoting CRC cells migration and invasion | [69] | |
– | – | Tumor suppressor | Decrease the activation of p-p38 and p-ERK | Inhibiting CRC proliferation and migration | [70] | |
 METTL14 | SOX4 | mRNA | Tumor suppressor | Degrade SOX4 mRNA | Inhibiting CRC metastasis | [71] |
XIST | lncRNA | Tumor suppressor | Mediate the degradation of XIST | Inhibiting CRC tumorigenicity and metastasis | [72] | |
miR-375 | miRNA | Tumor suppressor | Reduce miR-375 maturation | Inhibiting CRC cell growth, migration | [73] | |
 WTAP | – | – | Oncogene | Promote Wnt signaling pathway | Promoting CC development | [77] |
Erasers | ||||||
 FTO | MYC | mRNA | Oncogene | Enhance expression of MYC | Promoting CRC occurrence and progression | [59] |
 ALKBH5 | RP11 | lncRNA | Tumor suppressor | Decrease the nuclear accumulation of RP11 | Inhibiting CRC cells migration | [68] |
Readers | ||||||
 YTHDF1 | – | – | Oncogene | Promote Wnt/β-catenin pathway | Promoting CRC cells tumorigenicity | [74] |
 YTHDF3 | GAS5 | lncRNA | Oncogene | Facilitate the degradation of GAS5 | Promoting CRC progression | [75] |
 YTHDC1 | circNSUN2 | circRNA | Oncogene | Facilitate circNSUN2 nuclear export | Promoting CRC cells liver metastasis | [55] |
 YTHDC2 | HIF-1α | mRNA | Oncogene | Stabilize HIF-1α mRNA | Promoting CC cells proliferation | [76] |
 hnRNPCL2 | miR-483,676,877 | miRNA | Oncogene | Promote the miRNAs procession | Promoting CRC progression | [78] |