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Table 1 The roles of different m6A regulators in CRC

From: The crucial roles of N6-methyladenosine (m6A) modification in the carcinogenesis and progression of colorectal cancer

m6A regulators Genes Location Role Mechanism Function Refs
Writers
 METTL3 SOX2 mRNA Oncogene Stabilize SOX2 mRNA Promoting CRC tumorigenesis and metastasis [60]
MYC mRNA Oncogene Enhance expression of MYC Promoting CC cells proliferation [61]
CCNE1 mRNA Oncogene Stabilize CCNE1 mRNA Promoting CRC cells proliferation [62]
HK2/GLUT1 mRNA Oncogene Stabilize HK2 and GLUT1 mRNA Promoting CRC tumorigenesis [63]
GLUT1 mRNA Oncogene Promote GLUT1 mRNA translation Promoting CRC development [64]
CBX8 mRNA Oncogene Stabilize CBX8 mRNA Promoting CC stemness and chemoresistance [65]
SOCS2 mRNA Oncogene Degrade SOCS2 mRNA Promoting CC cells proliferation [66]
HSF1 mRNA Oncogene Promote HSF1 mRNA translation Promoting CRC development [67]
RP11 lncRNA Oncogene Promote the nuclear accumulation of RP11 Promoting CRC cells migration [68]
miR-1246 miRNA Oncogene Promote miR-1246 maturation Promoting CRC cells migration and invasion [69]
Tumor suppressor Decrease the activation of p-p38 and p-ERK Inhibiting CRC proliferation and migration [70]
 METTL14 SOX4 mRNA Tumor suppressor Degrade SOX4 mRNA Inhibiting CRC metastasis [71]
XIST lncRNA Tumor suppressor Mediate the degradation of XIST Inhibiting CRC tumorigenicity and metastasis [72]
miR-375 miRNA Tumor suppressor Reduce miR-375 maturation Inhibiting CRC cell growth, migration [73]
 WTAP Oncogene Promote Wnt signaling pathway Promoting CC development [77]
Erasers
 FTO MYC mRNA Oncogene Enhance expression of MYC Promoting CRC occurrence and progression [59]
 ALKBH5 RP11 lncRNA Tumor suppressor Decrease the nuclear accumulation of RP11 Inhibiting CRC cells migration [68]
Readers
 YTHDF1 Oncogene Promote Wnt/β-catenin pathway Promoting CRC cells tumorigenicity [74]
 YTHDF3 GAS5 lncRNA Oncogene Facilitate the degradation of GAS5 Promoting CRC progression [75]
 YTHDC1 circNSUN2 circRNA Oncogene Facilitate circNSUN2 nuclear export Promoting CRC cells liver metastasis [55]
 YTHDC2 HIF-1α mRNA Oncogene Stabilize HIF-1α mRNA Promoting CC cells proliferation [76]
 hnRNPCL2 miR-483,676,877 miRNA Oncogene Promote the miRNAs procession Promoting CRC progression [78]