Fig. 4

Schematic illustration of canonical and alternative spliced transcripts of peroxisome proliferator activated receptor gamma (PPARG) gene. In the central part, the PPARG gene structure is depicted. Four main PPARG canonical splice transcripts-PPARG1, PPARG2, PPARG3, PPARG3, and PPARG4-and alternative splice variants-PPARγ1(tr), γ1ORF4, γ2ORF4, γ3ORF4, and PPARγ∆5-are shown in the upper and below part, respectively. The corresponding encoded protein isoforms with functional domains are sketched in the right panel with divergent distribution patterns. The orange columns represent exons; the grey lines represent introns; the blue columns represent untranslated regions (UTRs); the grey column in PPARγ2 represents the 30 additional amino acids at N-terminus; the dark column in γORF4 represents the 21 amino acids at C terminus; the red rectangles represent stop codons; the purple rectangles represent premature termination codons (PTCs)