Fig. 6
From: Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy
Connecting the IKK complex and autophagy pathway. Confocal microscopy images of BMMs from WT or AR KO mice treated with or without 500 ng/ml LPS for 1 h, and co-stained for a polyUb and IKKβ, b polyUb and IKKγ, c p62 and IKKβ, and d p62 and IKKγ. Right graphs represent the quantification of co-localization of signals using Manders’ overlap coefficient. Scale bars = 20 µm. Data are expressed as the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01