Fig. 3
From: Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Increased p53 target gene expression in WE-68 cells. WE-68 cells were treated with 30 nM of AUY922, 1 µM of VE821, 7.5 µM of KU55933 and their combinations; A673 cells were treated with 15 nM of AUY922, 1 µM of VE821, 5 µM of KU55933 and their combinations. DMSO was used as control. a–d The mRNA expression of indicated genes was analyzed after 24 h by qPCR. All graphs show the mean ± SEM of three independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001)