Fig. 6

Model for SARS-CoV-2 Orf6 pathogenic mechanism. Panel on the left shows SARS-CoV-2 Orf6 binds XPO1 at the host nuclear pore complex, which leads to the observed cellular toxicity. Viral control of host nuclear transport is a common virus tactic to evade the host immune response and could potentially pave the way for increased viral replication. The right panel illustrates Selinexor’s mode of action, by directly binding and inhibiting XPO1 activity it prevents SARS-CoV-2 Orf6 from hijacking the host nuclear pore complex and thus inhibits Orf6 cellular toxicity