Fig. 5

Orf6-induced cellular toxicity is attenuated by treatment with Selinexor. HEK 293 T cells were transfected with 150 ng of control vector or Orf6 expression vector and treated with 0, 25, 50, 100, and 200 nM Selinexor (a) or with 0, 40, 200, 1000 nM Ivermectin (b). Cell viability was analyzed by luminescent cell viability assay (mean ± SD; n = 3 independent samples; T-test with Bonferroni correction between the non-treated (0 nM) and drug-treated cells; **P < 0.01, ***P < 0.001; ns non-significant)